Neuroanatomical correlates of impaired decision‐making and facial emotion recognition in early Parkinson’s disease
Identifieur interne : 000A21 ( Main/Exploration ); précédent : 000A20; suivant : 000A22Neuroanatomical correlates of impaired decision‐making and facial emotion recognition in early Parkinson’s disease
Auteurs : Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junque [Espagne] ; Eduardo Tolosa [Espagne] ; Maria-Jose Marti [Espagne] ; Francesc Valldeoriola [Espagne] ; Nuria Bargallo [Espagne] ; Mojtaba Zarei [Royaume-Uni]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2009-09.
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Abstract
Decision‐making and recognition of emotions are often impaired in patients with Parkinson’s disease (PD). The orbitofrontal cortex (OFC) and the amygdala are critical structures subserving these functions. This study was designed to test whether there are any structural changes in these areas that might explain the impairment of decision‐making and recognition of facial emotions in early PD. We used the Iowa Gambling Task (IGT) and the Ekman 60 faces test which are sensitive to the integrity of OFC and amygdala dysfunctions in 24 early PD patients and 24 controls. High‐resolution structural magnetic resonance images (MRI) were also obtained. Group analysis using voxel‐based morphometry (VBM) showed significant and corrected (P < 0.05 FEW‐small volume correction) gray matter (GM) loss in the right amygdala and bilaterally in the OFC in PD patients. Volumetric analyses were also performed but did not yield significant differences between groups. Left lateral GM volume in OFC showed a slight correlation with the IGT, and bilateral OFC GM was strongly correlated with Ekman test performance in PD patients. We conclude that: (i) impairment in decision‐making and recognition of facial emotions occurs at the early stages of PD, (ii) these neuropsychological deficits are accompanied by degeneration of OFC and amygdala, and (iii) bilateral OFC reductions are associated with impaired recognition of emotions, and GM volume loss in left lateral OFC is related to decision‐making impairment in PD.
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DOI: 10.1111/j.1460-9568.2009.06892.x
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The orbitofrontal cortex (OFC) and the amygdala are critical structures subserving these functions. This study was designed to test whether there are any structural changes in these areas that might explain the impairment of decision‐making and recognition of facial emotions in early PD. We used the Iowa Gambling Task (IGT) and the Ekman 60 faces test which are sensitive to the integrity of OFC and amygdala dysfunctions in 24 early PD patients and 24 controls. High‐resolution structural magnetic resonance images (MRI) were also obtained. Group analysis using voxel‐based morphometry (VBM) showed significant and corrected (P < 0.05 FEW‐small volume correction) gray matter (GM) loss in the right amygdala and bilaterally in the OFC in PD patients. Volumetric analyses were also performed but did not yield significant differences between groups. Left lateral GM volume in OFC showed a slight correlation with the IGT, and bilateral OFC GM was strongly correlated with Ekman test performance in PD patients. We conclude that: (i) impairment in decision‐making and recognition of facial emotions occurs at the early stages of PD, (ii) these neuropsychological deficits are accompanied by degeneration of OFC and amygdala, and (iii) bilateral OFC reductions are associated with impaired recognition of emotions, and GM volume loss in left lateral OFC is related to decision‐making impairment in PD.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Oxfordshire</li></region><settlement><li>Barcelone</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name></region><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zarei, Mojtaba" sort="Zarei, Mojtaba" uniqKey="Zarei M" first="Mojtaba" last="Zarei">Mojtaba Zarei</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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